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Major randomized controlled trials (the SURPASS program)

Mean weight change was 15.3 kg with semaglutide versus 2.6 kg with placebo, an estimated treatment difference of 12.7 kg

This might result in changes in the regularity, flow, or duration of periods

As an alternative, ribosomally synthesized and post-translationally modified peptides (RiPPs) offer a promising biosynthetic strategy for producing structurally modified peptides with improved properties (Montalbn-Lpez et al

"Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes." NEJM, 2016

This timeline applies regardless of whether the pen stays at room temperature or is returned to the refrigerator partway through